(Yes) In the case of full AHCI mode (which despite being the current HardDisk standard, often still requires a driver at windows installation time stupidly enough) so long as the drive is not the primary
OS drive, and it is not used for temp files, swap files, or restore points, and has no open file handles or locks (ie any
OS /NOT/ Windows) it should be totally hot swappable so long as you tell the host
OS to refresh the AHCI.